Getting older has its benefits, but aging sucks!
- Colostrum contains insulin-like growth factors (IGF-1 and IGF-2), transforming growth factors (TGF-alpha and TGF-beta), and epithelial growth factor (EGF) that slow down the effects of aging at the cellular level.
- Colostrum contains many essential and non-essential amino acids. These amino acids stimulate the body’s anabolic drive to slow down muscle degradation and help build new muscle tissue.
- The proline-rich polypeptides (PRPs) in colostrum enhance the body’s defense against oxidative stress, reducing the inflammatory processes that precede Alzheimer’s disease.
- Colostrum has been shown to help individuals boost satiety, optimize lean body mass, and modulate glucose homeostasis.
- Colostrum is a natural and healthy means of stimulating the brain to release serotonin and dopamine and prolong their re-uptake. Colostrum also activates the release of other chemicals in the brain that affect alertness and concentration.
- Colostrum has been shown to help reduce or eliminate the appearance of liver/age spots and provides an individual with more youthful and vibrant skin.
- Colostrum may even help an individual improve and restore sexual function.
- Bovine colostrum contains many components that inhibit the effects of aging and can help a person increase bone density, muscle tone, skin elasticity, and repair of DNA and RNA. Thus, colostrum offers a viable alternative to many costly, time-intensive anti-aging treatments.
- Colostrum works naturally to both replace the body’s own growth factors and stimulate the endocrine system to keep producing these vital and revitalizing hormones. There is solid evidence that the growth factors and immune-boosting agents act synergistically in colostrum to form a potent anti-aging substance.
- Colostrum supplementation protects against exercise – induced oxidative stress in skeletal muscle in mice
Mahenderan Appukutty, Ammu Kutty Radhakrishnan, Kalavathy Ramasamy, Rajesh Ramasamy, Abu Bakar Abdul Majeed, Mohd Ismail Noor, Nik Shanita Safii, Poh Bee Koon, Karuthan Chinna and Nagaraja HaleagraharaEmail https://doi.org/10.1186/1756-0500-5-649
Published: 22 November 2012
This study examined the effects of bovine colostrum on exercise –induced modulation of antioxidant parameters in skeletal muscle in mice. Adult male BALB/c mice were randomly divided into four groups (control, colostrum alone, exercise and exercise with colostrum) and each group had three subgroups (day 0, 21 and 42). Colostrum groups of mice were given a daily oral supplement of 50 mg/kg body weight of bovine colostrum and the exercise group of mice were made to exercise on the treadmill for 30 minutes per day. Total antioxidants, lipid hydroperoxides, xanthine oxidase and super oxide dismutase level was assayed from the homogenate of hind limb skeletal muscle.
Exercise—induced a significant oxidative stress in skeletal muscles as evidenced by the elevated lipid hydroperoxides and xanthine oxidase levels. There was a significant decrease in skeletal muscle total antioxidants and superoxide dismutase levels. Daily colostrum supplement significantly reduced the lipid hydroperoxides and xanthine oxidase enzyme level and increased the total antioxidant levels in the leg muscle.
Thus, the findings of this study showed that daily bovine colostrum supplementation was beneficial to skeletal muscle to reduce the oxidant-induced damage during muscular exercise.
- Current clinical trial for vaginal health – https://clinicaltrials.gov/ct2/show/NCT03281655
Noda, et al.. Transforming Growth factor Activity in Human Colostrum” Conn Vol. 75 (pg 19-1120), 1984. ‘
Francis, G.L., e t al. “Insulin-like growth factors 1 (IGF-l) and 2(IGF-2) in bovine colostrum” Biochemical Journal Vol. 251 (pp 95·108), 1988.
Oda, S.; et. al. “Insulin-like growth factor-l (IGF-1), growth hormone (GH). insulin and glucagon concentrations in bovine colostrum and in plasma of dairy cows and neonatal calves around parturition” Compo Bioch£.’YI1. Physiol. Vol 94A (4) (Pl’. 805-808) 1989.
Marcoty et. al. “IgF-l from cow colostrum- characterization; Ig-F potent stimulator of growth and differentiation of numerous cell types” Growth Regulation Longman Group UK, 1991.
Patureau-Mirand, Posone, Levieux, Attaix, et. al., “Effect of Colostrum Feeding on Protein Metabolism in the Small Intestine of Newborn Lambs” Biol . Neonate Vol. 57(1) pp. 30-36) 1990
Shawn, D .• “Colostrum: Bio-technology’s Next Step, Ironman. llug. 1992
Rosenthal. Brown Brunetti and Goldfine, “Fibroblast growth Factor Inhibit’ Insulin-Like Growth Factor-ll (IGF-ll) Gene Expression and Increases IGF-l Receptor Abundance in BC3H-I Muscle Cells” Dept. of Pediatrics. Univ. of California, SF Div. Of Diabetes and Endocrine Research, Mount Zion Medical Center, Univ, of CA., SF.
Palmer, E. L., et. al.. “Antiviral Activity of Colostrum and Serum Immunoglobulins A and G” Medical Virology, vol. S (pp 123-129), 1980
Rump, J.A.et. at: Treatment of Diarrhea in Human Immunodeficiency Virus-infected patients with Immunoglobulins from Bovine Colostrum” Clinical Investigator Vol 70 (pp588-594) 1992
Wilson, D.C., Ph.D., James “Immune System Breakthrough: Colostrum” Journal of Longevity, Vol. 4 (2), 1998.
Starocik, K; e.t. al., ‘Immunologically active non-peptide fragment of a proline-rlch polypeptide (PRP) from bovine colostrum- amino add sequence and immunoregulatory properties” Molecular Immunology, Vol. 20(12) (p1’1277- 1282). 1983.
Moulias R, Belmin J, Lesourd B, Laurent M. Meaume S. Smith .lA, Weidmann MJ, Cuneo RC. Hermine 0, Condamine L, Dupont WD, Rudman D, Rudman IW, Cohn L. Feller A, Lalitha PY, Gergans GA, Nagra HS. Goldberg AF, Mattson DE, Schlenker RA. Vance ML, “Effects of human growth hormone in men over 60 years old’ 323 (22); 1561 New England Journal of Medicine, 1990.
Rudman D, Feller AG. Nagraj HS. Gergans GA, Lalitha py. Goldberg AF. Schlenker RA. Cohn L, Rudman rw; Mat.tson DE “Effects of human growth hormone m men over 60 years old’ New England Journal of Medici””. ViJlume 323 (1): 1, 1990 Frank Benjamin S., “Doctor Fronk’s No-aging Diet’ 1981.
Metro A, Mikkulainen H, Pakkanen R, Aalot .T, Takala T. “Effect’ of bovine colostrum supplementation on IgF-1, IgG and saliva IgA during training’, University of Jyvaskyla, Finland.